Amyloid plaque formation precedes dendritic spine loss
نویسندگان
چکیده
منابع مشابه
Fibrillar Amyloid Plaque Formation Precedes Microglial Activation
In Alzheimer's disease (AD), hallmark β-amyloid deposits are characterized by the presence of activated microglia around them. Despite an extensive characterization of the relation of amyloid plaques with microglia, little is known about the initiation of this interaction. In this study, the detailed investigation of very small plaques in brain slices in AD transgenic mice of the line APP-PS1(d...
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INTRODUCTION Synaptic dysfunction and intracellular transport defects are early events in Alzheimer's disease (AD). Extracellular amyloid β (Aβ) oligomers cause spine alterations and impede the transport of proteins and organelles such as brain-derived neurotrophic factor (BDNF) and mitochondria that are required for synaptic function. Meanwhile, intraneuronal accumulation of Aβ precedes its ex...
متن کاملErratum: Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons
The original version of this article unfortunately contained a mistake in the presentation of Fig. 1 in both the PDF and HTML versions of this manuscript [1]. In the right panel of the corrected Fig. 1d, the images of Mock cells, which were visualized with GFP and stained with Abeta oligomer-specific antibody 11A1, were replaced with those of APPWT cells, and instead the images of APPWT cells w...
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ژورنال
عنوان ژورنال: Acta Neuropathologica
سال: 2012
ISSN: 0001-6322,1432-0533
DOI: 10.1007/s00401-012-1047-8